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Effective sample size for computing prior hyperarameters in Bayesian phase I-II dose-finding

BACKGROUND: The efficacy-toxicity trade-off based design is a practical Bayesian phase I-II dose-finding methodology. Because the design's performance is very sensitive to prior hyperparameters and the shape of the target trade-off contour, specifying these two design elements properly is essen...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Clin Trials
Prif Awduron: Thall, Peter F., Herrick, Richard C., Nguyen, Hoang Q., Venier, John J., Norris, J. Clift
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4229398/
https://ncbi.nlm.nih.gov/pubmed/25179541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1740774514547397
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