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CANDLES, an assay for monitoring GPCR induced cAMP generation in cell cultures
BACKGROUND: G protein-coupled receptors (GPCRs) represent a physiologically and pharmacologically important family of receptors that upon coupling to Gα(S) stimulate cAMP production catalyzed by adenylyl cyclase. Thus, developing assays to monitor cAMP production is crucial to screen for ligands in...
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| Publicat a: | Cell Commun Signal |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BioMed Central
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4228090/ https://ncbi.nlm.nih.gov/pubmed/25366423 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-014-0070-x |
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