Trigger-helix folding pathway and SI3 mediate catalysis and hairpin-stabilized pausing by Escherichia coli RNA polymerase

The conformational dynamics of the polymorphous trigger loop (TL) in RNA polymerase (RNAP) underlie multiple steps in the nucleotide addition cycle and diverse regulatory mechanisms. These mechanisms include nascent RNA hairpin-stabilized pausing, which inhibits TL folding into the trigger helices (...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Windgassen, Tricia A., Mooney, Rachel Anne, Nayak, Dhananjaya, Palangat, Murali, Zhang, Jinwei, Landick, Robert
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
Schlagworte:
Nucleic Acid Enzymes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4227799/
https://ncbi.nlm.nih.gov/pubmed/25336618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku997
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