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RNA polymerase accommodates a pause RNA hairpin by global conformational rearrangements that prolong pausing

Sequence-specific pausing by RNA polymerase (RNAP) during transcription plays crucial and diverse roles in gene expression. In bacteria, RNA structures are thought to fold within the RNA exit channel of the RNAP and can increase pause lifetimes significantly. The biophysical mechanism of pausing is...

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Bibliografski detalji
Izdano u:Mol Cell
Glavni autori: Kang, Jin Young, Mishanina, Tatiana V., Bellecourt, Michael J., Mooney, Rachel Anne, Darst, Seth A., Landick, Robert
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5903582/
https://ncbi.nlm.nih.gov/pubmed/29499135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.01.018
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