RNA polymerase accommodates a pause RNA hairpin by global conformational rearrangements that prolong pausing

Sequence-specific pausing by RNA polymerase (RNAP) during transcription plays crucial and diverse roles in gene expression. In bacteria, RNA structures are thought to fold within the RNA exit channel of the RNAP and can increase pause lifetimes significantly. The biophysical mechanism of pausing is...

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Détails bibliographiques
Publié dans:Mol Cell
Auteurs principaux: Kang, Jin Young, Mishanina, Tatiana V., Bellecourt, Michael J., Mooney, Rachel Anne, Darst, Seth A., Landick, Robert
Format: Artigo
Langue:Inglês
Publié: 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5903582/
https://ncbi.nlm.nih.gov/pubmed/29499135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.01.018
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