Trigger-helix folding pathway and SI3 mediate catalysis and hairpin-stabilized pausing by Escherichia coli RNA polymerase

The conformational dynamics of the polymorphous trigger loop (TL) in RNA polymerase (RNAP) underlie multiple steps in the nucleotide addition cycle and diverse regulatory mechanisms. These mechanisms include nascent RNA hairpin-stabilized pausing, which inhibits TL folding into the trigger helices (...

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Publicado en:Nucleic Acids Res
Autores principales: Windgassen, Tricia A., Mooney, Rachel Anne, Nayak, Dhananjaya, Palangat, Murali, Zhang, Jinwei, Landick, Robert
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2014
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4227799/
https://ncbi.nlm.nih.gov/pubmed/25336618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku997
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