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Role of the RNA polymerase trigger loop in nucleotidyl transfer, transcript cleavage, and transcriptional pausing

The trigger loop (TL) is a polymorphous component of RNA polymerase (RNAP) that makes direct substrate contacts and promotes nucleotide addition when folded into an α-helical hairpin (trigger helices; TH). However, the roles of the TL/TH in transcript cleavage, catalysis, substrate selectivity, and...

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Detalhes bibliográficos
Main Authors: Zhang, Jinwei, Palangat, Murali, Landick, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904963/
https://ncbi.nlm.nih.gov/pubmed/19966797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1732
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