Bax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic function

In non-apoptotic cells, Bak constitutively resides in the mitochondrial outer membrane. In contrast, Bax is in a dynamic equilibrium between the cytosol and mitochondria, and is commonly predominant in the cytosol. In response to an apoptotic stimulus, Bax and Bak change conformation, leading to Bax...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Ma, S B, Nguyen, T N, Tan, I, Ninnis, R, Iyer, S, Stroud, D A, Menard, M, Kluck, R M, Ryan, M T, Dewson, G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4227151/
https://ncbi.nlm.nih.gov/pubmed/25146925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.119
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados