Bax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic function

In non-apoptotic cells, Bak constitutively resides in the mitochondrial outer membrane. In contrast, Bax is in a dynamic equilibrium between the cytosol and mitochondria, and is commonly predominant in the cytosol. In response to an apoptotic stimulus, Bax and Bak change conformation, leading to Bax...

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Vydáno v:Cell Death Differ
Hlavní autoři: Ma, S B, Nguyen, T N, Tan, I, Ninnis, R, Iyer, S, Stroud, D A, Menard, M, Kluck, R M, Ryan, M T, Dewson, G
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2014
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Original Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4227151/
https://ncbi.nlm.nih.gov/pubmed/25146925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.119
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