Systems Level Metabolic Phenotype of Methotrexate Administration in the Context of Non-alcoholic Steatohepatitis in the Rat

Adverse drug reactions (ADRs) represent a significant clinical challenge with respect to patient morbidity and mortality. We investigated the hepatotoxicity and systems level metabolic phenotype of methotrexate (MTX) in the context of a prevalent liver disease; non-alcoholic steatohepatitis (NASH)....

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Toxicol Sci
Main Authors: Kyriakides, Michael, Hardwick, Rhiannon N., Jin, Zhaosheng, Goedken, Michael J., Holmes, Elaine, Cherrington, Nathan J., Coen, Muireann
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2014
Teme:
103
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4226764/
https://ncbi.nlm.nih.gov/pubmed/25145655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfu160
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