Dystrophin Is a Tumor Suppressor in Human Cancers with Myogenic Programs

Many common human mesenchymal tumors, including gastrointestinal stromal tumor (GIST), rhabdomyosarcoma (RMS), and leiomyosarcoma (LMS), feature myogenic differentiation(1–3). Here we report that intragenic deletion of the dystrophin-encoding and muscular dystrophy-associated DMD gene is a frequent...

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Veröffentlicht in:Nat Genet
Hauptverfasser: Wang, Yuexiang, Marino-Enriquez, Adrian, Bennett, Richard R., Zhu, Meijun, Shen, Yiping, Eilers, Grant, Lee, Jen-Chieh, Henze, Joern, Fletcher, Benjamin S., Gu, Zhizhan, Fox, Edward A., Antonescu, Cristina R., Fletcher, Christopher D.M., Guo, Xiangqian, Raut, Chandrajit P., Demetri, George D., van de Rijn, Matt, Ordog, Tamas, Kunkel, Louis M., Fletcher, Jonathan A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4225780/
https://ncbi.nlm.nih.gov/pubmed/24793134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2974
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