Dystrophin Is a Tumor Suppressor in Human Cancers with Myogenic Programs

Many common human mesenchymal tumors, including gastrointestinal stromal tumor (GIST), rhabdomyosarcoma (RMS), and leiomyosarcoma (LMS), feature myogenic differentiation(1–3). Here we report that intragenic deletion of the dystrophin-encoding and muscular dystrophy-associated DMD gene is a frequent...

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Publicat a:Nat Genet
Autors principals: Wang, Yuexiang, Marino-Enriquez, Adrian, Bennett, Richard R., Zhu, Meijun, Shen, Yiping, Eilers, Grant, Lee, Jen-Chieh, Henze, Joern, Fletcher, Benjamin S., Gu, Zhizhan, Fox, Edward A., Antonescu, Cristina R., Fletcher, Christopher D.M., Guo, Xiangqian, Raut, Chandrajit P., Demetri, George D., van de Rijn, Matt, Ordog, Tamas, Kunkel, Louis M., Fletcher, Jonathan A.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4225780/
https://ncbi.nlm.nih.gov/pubmed/24793134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2974
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