Dystrophin Is a Tumor Suppressor in Human Cancers with Myogenic Programs

Many common human mesenchymal tumors, including gastrointestinal stromal tumor (GIST), rhabdomyosarcoma (RMS), and leiomyosarcoma (LMS), feature myogenic differentiation(1–3). Here we report that intragenic deletion of the dystrophin-encoding and muscular dystrophy-associated DMD gene is a frequent...

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Detalhes bibliográficos
Publicado no:Nat Genet
Main Authors: Wang, Yuexiang, Marino-Enriquez, Adrian, Bennett, Richard R., Zhu, Meijun, Shen, Yiping, Eilers, Grant, Lee, Jen-Chieh, Henze, Joern, Fletcher, Benjamin S., Gu, Zhizhan, Fox, Edward A., Antonescu, Cristina R., Fletcher, Christopher D.M., Guo, Xiangqian, Raut, Chandrajit P., Demetri, George D., van de Rijn, Matt, Ordog, Tamas, Kunkel, Louis M., Fletcher, Jonathan A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4225780/
https://ncbi.nlm.nih.gov/pubmed/24793134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2974
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