Binding site asymmetry in human transthyretin: insights from a joint neutron and X-ray crystallographic analysis using perdeuterated protein

Human transthyretin has an intrinsic tendency to form amyloid fibrils and is heavily implicated in senile systemic amyloidosis. Here, detailed neutron structural studies of perdeuterated transthyretin are described. The analyses, which fully exploit the enhanced visibility of isotopically replaced h...

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Detaylı Bibliyografya
Yayımlandı:IUCrJ
Asıl Yazarlar: Haupt, Melina, Blakeley, Matthew P., Fisher, Stuart J., Mason, Sax A., Cooper, Jon B., Mitchell, Edward P., Forsyth, V. Trevor
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: International Union of Crystallography 2014
Konular:
Research Papers
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4224461/
https://ncbi.nlm.nih.gov/pubmed/25485123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2052252514021113
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