Binding site asymmetry in human transthyretin: insights from a joint neutron and X-ray crystallographic analysis using perdeuterated protein

Human transthyretin has an intrinsic tendency to form amyloid fibrils and is heavily implicated in senile systemic amyloidosis. Here, detailed neutron structural studies of perdeuterated transthyretin are described. The analyses, which fully exploit the enhanced visibility of isotopically replaced h...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:IUCrJ
Autori principali: Haupt, Melina, Blakeley, Matthew P., Fisher, Stuart J., Mason, Sax A., Cooper, Jon B., Mitchell, Edward P., Forsyth, V. Trevor
Natura: Artigo
Lingua:Inglês
Pubblicazione: International Union of Crystallography 2014
Soggetti:
Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4224461/
https://ncbi.nlm.nih.gov/pubmed/25485123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2052252514021113
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi