Inhibition of d-xylose isomerase by polyols: atomic details by joint X-ray/neutron crystallography

d-Xylose isomerase (XI) converts the aldo-sugars xylose and glucose to their keto analogs xylulose and fructose, but is strongly inhibited by the polyols xylitol and sorbitol, especially at acidic pH. In order to understand the atomic details of polyol binding to the XI active site, a 2.0 Å resoluti...

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Autores principales: Kovalevsky, Andrey, Hanson, B. Leif, Mason, Sax A., Forsyth, V. Trevor, Fisher, Zoe, Mustyakimov, Marat, Blakeley, Matthew P., Keen, David A., Langan, Paul
Formato: Artigo
Lenguaje:Inglês
Publicado: International Union of Crystallography 2012
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3489103/
https://ncbi.nlm.nih.gov/pubmed/22948921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0907444912024808
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