Inhibition of d-xylose isomerase by polyols: atomic details by joint X-ray/neutron crystallography

d-Xylose isomerase (XI) converts the aldo-sugars xylose and glucose to their keto analogs xylulose and fructose, but is strongly inhibited by the polyols xylitol and sorbitol, especially at acidic pH. In order to understand the atomic details of polyol binding to the XI active site, a 2.0 Å resoluti...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Kovalevsky, Andrey, Hanson, B. Leif, Mason, Sax A., Forsyth, V. Trevor, Fisher, Zoe, Mustyakimov, Marat, Blakeley, Matthew P., Keen, David A., Langan, Paul
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: International Union of Crystallography 2012
Gaiak:
Research Papers
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3489103/
https://ncbi.nlm.nih.gov/pubmed/22948921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0907444912024808
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