Inhibition of d-xylose isomerase by polyols: atomic details by joint X-ray/neutron crystallography

d-Xylose isomerase (XI) converts the aldo-sugars xylose and glucose to their keto analogs xylulose and fructose, but is strongly inhibited by the polyols xylitol and sorbitol, especially at acidic pH. In order to understand the atomic details of polyol binding to the XI active site, a 2.0 Å resoluti...

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Hlavní autoři: Kovalevsky, Andrey, Hanson, B. Leif, Mason, Sax A., Forsyth, V. Trevor, Fisher, Zoe, Mustyakimov, Marat, Blakeley, Matthew P., Keen, David A., Langan, Paul
Médium: Artigo
Jazyk:Inglês
Vydáno: International Union of Crystallography 2012
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Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3489103/
https://ncbi.nlm.nih.gov/pubmed/22948921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0907444912024808
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