Inhibition of d-xylose isomerase by polyols: atomic details by joint X-ray/neutron crystallography

d-Xylose isomerase (XI) converts the aldo-sugars xylose and glucose to their keto analogs xylulose and fructose, but is strongly inhibited by the polyols xylitol and sorbitol, especially at acidic pH. In order to understand the atomic details of polyol binding to the XI active site, a 2.0 Å resoluti...

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Main Authors: Kovalevsky, Andrey, Hanson, B. Leif, Mason, Sax A., Forsyth, V. Trevor, Fisher, Zoe, Mustyakimov, Marat, Blakeley, Matthew P., Keen, David A., Langan, Paul
Format: Artigo
Sprog:Inglês
Udgivet: International Union of Crystallography 2012
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3489103/
https://ncbi.nlm.nih.gov/pubmed/22948921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0907444912024808
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