Rap1b in Smooth Muscle and Endothelium is Required for Maintenance of Vascular Tone and Normal Blood Pressure

OBJECTIVE: Small GTPase Rap1b controls several basic cellular phenomena and its deletion in mice leads to several cardiovascular defects, including impaired adhesion of blood cells and defective angiogenesis. We found that Rap1b knockout (Rap1b(−/−)) mice develop cardiac hypertrophy and hypertension...

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Detalhes bibliográficos
Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: Lakshmikanthan, Sribalaji, Zieba, Bartosz J., Ge, Zhi-Dong, Momotani, Ko, Zheng, Xiaodong, Lund, Hayley, Artamonov, Mykhaylo V., Maas, Jason E., Szabo, Aniko, Zhang, David X., Auchampach, John A., Mattson, David L., Somlyo, Avril V., Chrzanowska-Wodnicka, Magdalena
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4224284/
https://ncbi.nlm.nih.gov/pubmed/24790136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.114.303678
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