Rap1B promotes VEGF-induced endothelial permeability and is required for dynamic regulation of the endothelial barrier

Vascular endothelial growth factor (VEGF), a key angiogenic and permeability factor, plays an important role in new blood vessel formation. However, abnormal VEGF-induced VEGFR2 signaling leads to hyperpermeability. We have shown previously that Rap1, best known for promoting cell adhesion and vesse...

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Detalhes bibliográficos
Publicado no:J Cell Sci
Main Authors: Lakshmikanthan, Sribalaji, Sobczak, Magdalena, Li Calzi, Sergio, Shaw, Lynn, Grant, Maria B., Chrzanowska-Wodnicka, Magdalena
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5818062/
https://ncbi.nlm.nih.gov/pubmed/29222111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.207605
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