Rap1 promotes VEGFR2 activation and angiogenesis by a mechanism involving integrin α(v)β(3)

Vascular endothelial growth factor (VEGF) acting through VEGF receptor 2 (VEGFR2) on endothelial cells (ECs) is a key regulator of angiogenesis, a process essential for wound healing and tumor metastasis. Rap1a and Rap1b, 2 highly homologous small G proteins, are both required for angiogenesis in vi...

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Detalhes bibliográficos
Main Authors: Lakshmikanthan, Sribalaji, Sobczak, Magdalena, Chun, Changzoon, Henschel, Angela, Dargatz, Jillian, Ramchandran, Ramani, Chrzanowska-Wodnicka, Magdalena
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Vascular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3158727/
https://ncbi.nlm.nih.gov/pubmed/21636859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-04-349282
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