Rap1 promotes endothelial mechanosensing complex formation, NO release and normal endothelial function

Decreased nitric oxide (NO) bioavailability underlies a number of cardiovascular pathologies, including hypertension. The shear stress exerted by flowing blood is the main determinant of NO release. Rap1 promotes integrin- and cadherin-mediated signaling. Here, we show that Rap1 is a critical regula...

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Detalhes bibliográficos
Publicado no:EMBO Rep
Main Authors: Lakshmikanthan, Sribalaji, Zheng, Xiaodong, Nishijima, Yoshinori, Sobczak, Magdalena, Szabo, Aniko, Vasquez-Vivar, Jeannette, Zhang, David X, Chrzanowska-Wodnicka, Magdalena
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Scientific Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4428051/
https://ncbi.nlm.nih.gov/pubmed/25807985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201439846
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