Distinct Signaling Functions of Rap1 Isoforms in NO Release From Endothelium

Small GTPase Rap1 plays a prominent role in endothelial cell (EC) homeostasis by promoting NO release. Endothelial deletion of the two highly homologous Rap1 isoforms, Rap1A and Rap1B, leads to endothelial dysfunction ex vivo and hypertension in vivo. Mechanistically, we showed that Rap1B promotes N...

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Detalhes bibliográficos
Publicado no:Front Cell Dev Biol
Main Authors: Kosuru, Ramoji, Singh, Bandana, Lakshmikanthan, Sribalaji, Nishijima, Yoshinori, Vasquez-Vivar, Jeannette, Zhang, David X., Chrzanowska, Magdalena
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8247587/
https://ncbi.nlm.nih.gov/pubmed/34222255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.687598
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