Hippocampal Extracellular Matrix Levels and Stochasticity in Synaptic Protein Expression Increase with Age and Are Associated with Age-dependent Cognitive Decline

Age-related cognitive decline is a serious health concern in our aging society. Decreased cognitive function observed during healthy brain aging is most likely caused by changes in brain connectivity and synaptic dysfunction in particular brain regions. Here we show that aged C57BL/6J wild-type mice...

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Veröffentlicht in:Mol Cell Proteomics
Hauptverfasser: Végh, Marlene J., Rausell, Antonio, Loos, Maarten, Heldring, Céline M., Jurkowski, Wiktor, van Nierop, Pim, Paliukhovich, Iryna, Li, Ka Wan, del Sol, Antonio, Smit, August B., Spijker, Sabine, van Kesteren, Ronald E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Biochemistry and Molecular Biology 2014
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4223485/
https://ncbi.nlm.nih.gov/pubmed/25044018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M113.032086
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