Reducing hippocampal extracellular matrix reverses early memory deficits in a mouse model of Alzheimer’s disease

Alzheimer’s disease is caused by increased production or reduced clearance of amyloid-β, which results in the formation amyloid-β plaques and triggers a cascade of downstream events leading to progressive neurodegeneration. The earliest clinical symptoms of Alzheimer’s disease, i.e., memory loss, ar...

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Autores principales: Végh, Marlene J, Heldring, Céline M, Kamphuis, Willem, Hijazi, Sara, Timmerman, Arie J, Li, Ka Wan, van Nierop, Pim, Mansvelder, Huibert D, Hol, Elly M, Smit, August B, van Kesteren, Ronald E
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4149201/
https://ncbi.nlm.nih.gov/pubmed/24974208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-014-0076-z
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