Hyperexcitable Parvalbumin Interneurons Render Hippocampal Circuitry Vulnerable to Amyloid Beta

Parvalbumin (PV) interneuron dysfunction is associated with various brain disorders, including Alzheimer disease (AD). Here, we asked whether early PV neuron hyperexcitability primes the hippocampus for amyloid beta-induced functional impairment. We show that prolonged chemogenetic activation of PV...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:iScience
Prif Awduron: Hijazi, Sara, Heistek, Tim S., van der Loo, Rolinka, Mansvelder, Huibert D., Smit, August B., van Kesteren, Ronald E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7327841/
https://ncbi.nlm.nih.gov/pubmed/32593000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101271
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