Hyperexcitable Parvalbumin Interneurons Render Hippocampal Circuitry Vulnerable to Amyloid Beta

Parvalbumin (PV) interneuron dysfunction is associated with various brain disorders, including Alzheimer disease (AD). Here, we asked whether early PV neuron hyperexcitability primes the hippocampus for amyloid beta-induced functional impairment. We show that prolonged chemogenetic activation of PV...

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Publicado en:iScience
Main Authors: Hijazi, Sara, Heistek, Tim S., van der Loo, Rolinka, Mansvelder, Huibert D., Smit, August B., van Kesteren, Ronald E.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7327841/
https://ncbi.nlm.nih.gov/pubmed/32593000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101271
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