Hyperexcitable Parvalbumin Interneurons Render Hippocampal Circuitry Vulnerable to Amyloid Beta

Parvalbumin (PV) interneuron dysfunction is associated with various brain disorders, including Alzheimer disease (AD). Here, we asked whether early PV neuron hyperexcitability primes the hippocampus for amyloid beta-induced functional impairment. We show that prolonged chemogenetic activation of PV...

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Detaylı Bibliyografya
Yayımlandı:iScience
Asıl Yazarlar: Hijazi, Sara, Heistek, Tim S., van der Loo, Rolinka, Mansvelder, Huibert D., Smit, August B., van Kesteren, Ronald E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7327841/
https://ncbi.nlm.nih.gov/pubmed/32593000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101271
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