Statin Use Is Not Associated with Improved Progression Free Survival in Cetuximab Treated KRAS Mutant Metastatic Colorectal Cancer Patients: Results from the CAIRO2 Study

Statins may inhibit the expression of the mutant KRAS phenotype by preventing the prenylation and thus the activation of the KRAS protein. This study was aimed at retrospectively evaluating the effect of statin use on outcome in KRAS mutant metastatic colorectal cancer patients (mCRC) treated with c...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Krens, Lisanne L., Simkens, Lieke H. J., Baas, Jara M., Koomen, Els R., Gelderblom, Hans, Punt, Cornelis J. A., Guchelaar, Henk-Jan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4223044/
https://ncbi.nlm.nih.gov/pubmed/25375154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0112201
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