Statin Use Is Not Associated with Improved Progression Free Survival in Cetuximab Treated KRAS Mutant Metastatic Colorectal Cancer Patients: Results from the CAIRO2 Study

Statins may inhibit the expression of the mutant KRAS phenotype by preventing the prenylation and thus the activation of the KRAS protein. This study was aimed at retrospectively evaluating the effect of statin use on outcome in KRAS mutant metastatic colorectal cancer patients (mCRC) treated with c...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Krens, Lisanne L., Simkens, Lieke H. J., Baas, Jara M., Koomen, Els R., Gelderblom, Hans, Punt, Cornelis J. A., Guchelaar, Henk-Jan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4223044/
https://ncbi.nlm.nih.gov/pubmed/25375154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0112201
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