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Hydrogen–Deuterium Exchange and Mass Spectrometry Reveal the pH-Dependent Conformational Changes of Diphtheria Toxin T Domain
[Image: see text] The translocation (T) domain of diphtheria toxin plays a critical role in moving the catalytic domain across the endosomal membrane. Translocation/insertion is triggered by a decrease in pH in the endosome where conformational changes of T domain occur through several kinetic inter...
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| Gepubliceerd in: | Biochemistry |
|---|---|
| Hoofdauteurs: | , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American
Chemical Society
2014
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| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4222528/ https://ncbi.nlm.nih.gov/pubmed/25290210 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi500893y |
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