Linear mtDNA fragments and unusual mtDNA rearrangements associated with pathological deficiency of MGME1 exonuclease

MGME1, also known as Ddk1 or C20orf72, is a mitochondrial exonuclease found to be involved in the processing of mitochondrial DNA (mtDNA) during replication. Here, we present detailed insights on the role of MGME1 in mtDNA maintenance. Upon loss of MGME1, elongated 7S DNA species accumulate owing to...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Hum Mol Genet
Main Authors: Nicholls, Thomas J., Zsurka, Gábor, Peeva, Viktoriya, Schöler, Susanne, Szczesny, Roman J., Cysewski, Dominik, Reyes, Aurelio, Kornblum, Cornelia, Sciacco, Monica, Moggio, Maurizio, Dziembowski, Andrzej, Kunz, Wolfram S., Minczuk, Michal
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2014
Fag:
Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4222359/
https://ncbi.nlm.nih.gov/pubmed/24986917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu336
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker