Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria

Replication of mammalian mitochondrial DNA (mtDNA) is an essential process that requires high fidelity and control at multiple levels to ensure proper mitochondrial function. Mutations in the mitochondrial genome maintenance exonuclease 1 (MGME1) gene were recently reported in mitochondrial disease...

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Udgivet i:Nat Commun
Main Authors: Matic, Stanka, Jiang, Min, Nicholls, Thomas J., Uhler, Jay P., Dirksen-Schwanenland, Caren, Polosa, Paola Loguercio, Simard, Marie-Lune, Li, Xinping, Atanassov, Ilian, Rackham, Oliver, Filipovska, Aleksandra, Stewart, James B., Falkenberg, Maria, Larsson, Nils-Göran, Milenkovic, Dusanka
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5865154/
https://ncbi.nlm.nih.gov/pubmed/29572490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03552-x
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