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Is There Still Any Role for Oxidative Stress in Mitochondrial DNA-Dependent Aging?

Recent deep sequencing data has provided compelling evidence that the spectrum of somatic point mutations in mitochondrial DNA (mtDNA) in aging tissues lacks G > T transversion mutations. This fact cannot, however, be used as an argument for the missing contribution of reactive oxygen species (RO...

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Detalhes bibliográficos
Publicado no:Genes (Basel)
Main Authors: Zsurka, Gábor, Peeva, Viktoriya, Kotlyar, Alexander, Kunz, Wolfram S.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5924517/
https://ncbi.nlm.nih.gov/pubmed/29561808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes9040175
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