Linear mitochondrial DNA is rapidly degraded by components of the replication machinery

Emerging gene therapy approaches that aim to eliminate pathogenic mutations of mitochondrial DNA (mtDNA) rely on efficient degradation of linearized mtDNA, but the enzymatic machinery performing this task is presently unknown. Here, we show that, in cellular models of restriction endonuclease-induce...

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Библиографические подробности
Опубликовано в: :Nat Commun
Главные авторы: Peeva, Viktoriya, Blei, Daniel, Trombly, Genevieve, Corsi, Sarah, Szukszto, Maciej J., Rebelo-Guiomar, Pedro, Gammage, Payam A., Kudin, Alexei P., Becker, Christian, Altmüller, Janine, Minczuk, Michal, Zsurka, Gábor, Kunz, Wolfram S.
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5928156/
https://ncbi.nlm.nih.gov/pubmed/29712893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04131-w
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