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Loss of LKB1 in High Grade Endometrial Carcinoma: LKB1 is a Novel Transcriptional Target of p53

BACKGROUND: LKB1 is a serine/threonine kinase that functions as a tumor suppressor, which regulates cell polarity, proliferation and metabolism. Mutations in LKB1 are associated with Peutz-Jeghers syndrome, as well as sporadic cervical and lung cancers. While LKB1-null mice develop invasive endometr...

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Bibliografiske detaljer
Udgivet i:Cancer
Main Authors: Co, Ngai Na, Iglesias, David, Celestino, Joseph, Kwan, Suet Y., Mok, Samuel C., Schmandt, Rosemarie, Lu, Karen H.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4221493/
https://ncbi.nlm.nih.gov/pubmed/25042259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.28854
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