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Endometrial cancers with activating KRas mutations have activated estrogen signaling and paradoxical response to MEK inhibition
OBJECTIVE: To determine if activating KRas mutation alters estrogen signaling in endometrial cancer (EC) and to explore the potential therapeutic impact of these alterations. METHODS: The Cancer Genome Atlas (TCGA) was queried for changes in estrogen-regulated genes in EC based on KRas mutation stat...
שמור ב:
| הוצא לאור ב: | Int J Gynecol Cancer |
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| Main Authors: | , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2017
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5438270/ https://ncbi.nlm.nih.gov/pubmed/28498246 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/IGC.0000000000000960 |
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