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Loss of LKB1 in High Grade Endometrial Carcinoma: LKB1 is a Novel Transcriptional Target of p53
BACKGROUND: LKB1 is a serine/threonine kinase that functions as a tumor suppressor, which regulates cell polarity, proliferation and metabolism. Mutations in LKB1 are associated with Peutz-Jeghers syndrome, as well as sporadic cervical and lung cancers. While LKB1-null mice develop invasive endometr...
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| Publicado no: | Cancer |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4221493/ https://ncbi.nlm.nih.gov/pubmed/25042259 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.28854 |
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