Exosomal transfer of stroma-derived miR21 confers paclitaxel resistance in ovarian cancer cells through targeting APAF1

Advanced ovarian cancer usually spreads to the visceral adipose tissue of the omentum. However, the omental stromal cell-derived molecular determinants that modulate ovarian cancer growth have not been characterized. Here, using next-generation sequencing technology, we identify significantly higher...

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Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Au Yeung, Chi Lam, Co, Ngai-Na, Tsuruga, Tetsushi, Yeung, Tsz-Lun, Kwan, Suet-Ying, Leung, Cecilia S., Li, Yong, Lu, Edward S., Kwan, Kenny, Wong, Kwong-Kwok, Schmandt, Rosemarie, Lu, Karen H., Mok, Samuel C.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2016
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4820618/
https://ncbi.nlm.nih.gov/pubmed/27021436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11150
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