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Small Molecule BMH-compounds that Inhibit RNA Polymerase I and Cause Nucleolar Stress
Activation of the p53 pathway has been considered a therapeutic strategy to target cancers. We have previously identified several p53 activating small molecules in a cell-based screen. Two of the compounds activated p53 by causing DNA damage, but this modality was absent in the other four. We recent...
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| Published in: | Mol Cancer Ther |
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| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4221476/ https://ncbi.nlm.nih.gov/pubmed/25277384 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-14-0256 |
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