Small Molecule BMH-compounds that Inhibit RNA Polymerase I and Cause Nucleolar Stress

Activation of the p53 pathway has been considered a therapeutic strategy to target cancers. We have previously identified several p53 activating small molecules in a cell-based screen. Two of the compounds activated p53 by causing DNA damage, but this modality was absent in the other four. We recent...

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Bibliographic Details
Published in:Mol Cancer Ther
Main Authors: Peltonen, Karita, Colis, Laureen, Liu, Hester, Jäämaa, Sari, Zhang, Zhewei, Hällström, Taija af, Moore, Henna M., Sirajuddin, Paul, Laiho, Marikki
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4221476/
https://ncbi.nlm.nih.gov/pubmed/25277384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-14-0256
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