DNA intercalator BMH-21 inhibits RNA polymerase I independent of DNA damage response

DNA intercalation is a major therapeutic modality for cancer therapeutic drugs. The therapeutic activity comes at a cost of normal tissue toxicity and genotoxicity. We have recently described a planar heterocyclic small molecule DNA intercalator, BMH-21, that binds ribosomal DNA and inhibits RNA pol...

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Main Authors: Colis, Laureen, Peltonen, Karita, Sirajuddin, Paul, Liu, Hester, Sanders, Sara, Ernst, Glen, Barrow, James C., Laiho, Marikki
Formáid: Artigo
Teanga:Inglês
Foilsithe: Impact Journals LLC 2014
Ábhair:
Research Paper
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4147329/
https://ncbi.nlm.nih.gov/pubmed/24952786
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