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A Targeting Modality for Destruction of RNA Polymerase I that Possesses Anticancer Activity
We define here the activity and mechanisms of action of a small molecule lead compound for cancer targeting. We show that the compound, BMH-21, has wide and potent antitumorigenic activity across NCI60 cancer cell lines and represses tumor growth in vivo. BMH-21 binds GC-rich sequences, which is pre...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2014
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3930145/ https://ncbi.nlm.nih.gov/pubmed/24434211 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2013.12.009 |
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