A Targeting Modality for Destruction of RNA Polymerase I that Possesses Anticancer Activity

We define here the activity and mechanisms of action of a small molecule lead compound for cancer targeting. We show that the compound, BMH-21, has wide and potent antitumorigenic activity across NCI60 cancer cell lines and represses tumor growth in vivo. BMH-21 binds GC-rich sequences, which is pre...

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Main Authors: Peltonen, Karita, Colis, Laureen, Liu, Hester, Trivedi, Rishi, Moubarek, Michael S., Moore, Henna M., Bai, Bayoan, Rudek, Michelle A., Bieberich, Charles J., Laiho, Marikki
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3930145/
https://ncbi.nlm.nih.gov/pubmed/24434211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2013.12.009
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