Identification of Novel p53 Pathway Activating Small-Molecule Compounds Reveals Unexpected Similarities with Known Therapeutic Agents

Manipulation of the activity of the p53 tumor suppressor pathway has demonstrated potential benefit in preclinical mouse tumor models and has entered human clinical trials. We describe here an improved, extensive small-molecule chemical compound library screen for p53 pathway activation in a human c...

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Detaylı Bibliyografya
Asıl Yazarlar: Peltonen, Karita, Colis, Laureen, Liu, Hester, Jäämaa, Sari, Moore, Henna M., Enbäck, Juulia, Laakkonen, Pirjo, Vaahtokari, Anne, Jones, Richard J., af Hällström, Taija M., Laiho, Marikki
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2010
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2946317/
https://ncbi.nlm.nih.gov/pubmed/20885994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012996
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