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Human prostate epithelium lacks Wee1A-mediated DNA damage-induced checkpoint enforcement

Cellular DNA damage triggers the DNA damage response pathway and leads to enforcement of cell cycle checkpoints, which are essential for the maintenance of genomic integrity and are activated in early stages of tumorigenesis. A special feature of prostate cancer is its high incidence and multifocali...

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Detalhes bibliográficos
Main Authors: Kiviharju-af Hällström, Taija M., Jäämaa, Sari, Mönkkönen, Mia, Peltonen, Karita, Andersson, Leif C., Medema, René H., Peehl, Donna M., Laiho, Marikki
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1855358/
https://ncbi.nlm.nih.gov/pubmed/17431037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609299104
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