Design, Synthesis, and Structure–Activity Relationships of Pyridoquinazolinecarboxamides as RNA Polymerase I Inhibitors

[Image: see text] RNA polymerase I (Pol I) is a dedicated polymerase that transcribes the 45S ribosomal (r) RNA precursor. The 45S rRNA precursor is subsequently processed into the mature 5.8S, 18S, and 28S rRNAs and assembled into ribosomes in the nucleolus. Pol I activity is commonly deregulated i...

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Detalhes bibliográficos
Main Authors: Colis, Laureen, Ernst, Glen, Sanders, Sara, Liu, Hester, Sirajuddin, Paul, Peltonen, Karita, DePasquale, Michael, Barrow, James C., Laiho, Marikki
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4059246/
https://ncbi.nlm.nih.gov/pubmed/24847734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm5004842
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