Temperature-Sensitive Mutants of Influenza A Virus: Evaluation of A/Victoria/3/75-ts-1[E] Recombinant Viruses in Volunteers

The Hong Kong/68-ts-1[E] virus and its Udorn/72 and Georgia/74 recombinants, which have a 38°C shutoff temperature and a ts lesion(s) on the genes coding for the P3 and NP proteins, were adequately attenuated and immunogenic in adult volunteers who lacked serum hemagglutination-inhibiting antibody (...

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Pubblicato in:	Infect Immun
Autori principali:	Murphy, Brian R., Markoff, Lewis J., Hosier, Nanette T., Rusten, Harold M., Chanock, Robert M., Kendal, Alan P., Douglas, R. Gordon, Betts, Robert F., Cate, Thomas R., Couch, Robert B., Levine, Myron M., Waterman, Daniel H., Holley, H. Preston
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1978
Soggetti:	Viral Infections
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC421911/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/669819/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.20.3.671-677.1978
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