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Production and Level of Genetic Stability of an Influenza A Virus Temperature-Sensitive Mutant Containing Two Genes with ts Mutations

Temperature-sensitive (ts) reassortant vaccine strains derived from the A/Udorn/72 ts-1A2 donor virus were not sufficiently stable genetically in humans. We therefore sought to produce a new, more stable donor virus. We had previously identified a stable ts virus with a ts P3 gene and in the current...

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發表在:Infect Immun
Main Authors: Murphy, Brian R., Markoff, Lewis J., Hosier, Nanette T., Massicot, Judith G., Chanock, Robert M.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology (ASM) 1982
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在線閱讀:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC347518/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7107005/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.37.1.235-242.1982
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