Temperature-Sensitive Mutants of Influenza A Virus: Evaluation of A/Victoria/3/75-ts-1[E] Recombinant Viruses in Volunteers

The Hong Kong/68-ts-1[E] virus and its Udorn/72 and Georgia/74 recombinants, which have a 38°C shutoff temperature and a ts lesion(s) on the genes coding for the P3 and NP proteins, were adequately attenuated and immunogenic in adult volunteers who lacked serum hemagglutination-inhibiting antibody (...

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Detalhes bibliográficos
Main Authors: Murphy, Brian R., Markoff, Lewis J., Hosier, Nanette T., Rusten, Harold M., Chanock, Robert M., Kendal, Alan P., Douglas, R. Gordon, Betts, Robert F., Cate, Thomas R., Couch, Robert B., Levine, Myron M., Waterman, Daniel H., Holley, H. Preston
Formato: Artigo
Idioma:Inglês
Publicado em: 1978
Assuntos:
Viral Infections
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC421911/
https://ncbi.nlm.nih.gov/pubmed/669819
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