Generation of a Single Chain Antibody Variable Fragment (scFv) to Sense Selectively RhoB Activation

Determining the cellular level of activated form of RhoGTPases is of key importance to understand their regulatory functions in cell physiopathology. We previously reported scFvC1, that selectively bind to the GTP-bound form of RhoA, RhoB and RhoC. In this present study we generate, by molecular evo...

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Bibliografski detalji
Izdano u:PLoS One
Glavni autori: Chinestra, Patrick, Olichon, Aurélien, Medale-Giamarchi, Claire, Lajoie-Mazenc, Isabelle, Gence, Rémi, Inard, Cyril, Ligat, Laetitia, Faye, Jean-Charles, Favre, Gilles
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218836/
https://ncbi.nlm.nih.gov/pubmed/25365345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0111034
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