ET-07 DOES OSMOTIC BLOOD-BRAIN BARRIER DISRUPTION ALLOWS EFFLUX PUMP SUBSTRATES DELIVERY TO THE TUMOR AND CNS?

Despite decades of research, the median survival of glioblastoma (GBM) patients remains 14.6 months. The presence of the blood-brain barrier (BBB) limits CNS antineoplastic drugs delivery. Many BBB characteristics are involved in the drug delivery limitation, amongst them the efflux pumps. Different...

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Detalhes bibliográficos
Main Authors: Blanchette, Marie, Gascon, Suzanne, Tremblay, Sébastien, Tremblay, Luc, Guérin, Brigitte, Lepage, Martin, Lecomte, Roger, Fortin, David
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Abstracts
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218170/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou255.7
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