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Metformin Disrupts Bile Acid Efflux by Repressing Bile Salt Export Pump Expression

PURPOSE: The bile salt export pump (BSEP), a key player in hepatic bile acid clearance, has been the center of research on drug-induced cholestasis. However, such studies focus primarily on the direct inhibition of BSEP, often overlooking the potential impact of transcriptional repression. This work...

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Vydáno v:Pharm Res
Hlavní autoři: Garzel, Brandy, Hu, Tao, Li, Linhao, Lu, Yuanfu, Heyward, Scott, Polli, James, Zhang, Lei, Huang, Shiew-Mei, Raufman, Jean-Pierre, Wang, Hongbing
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7357855/
https://ncbi.nlm.nih.gov/pubmed/31907698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-019-2753-x
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