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The Role of Bile Salt Export Pump Gene Repression in Drug-Induced Cholestatic Liver Toxicity
The bile salt export pump (BSEP, ABCB11) is predominantly responsible for the efflux of bile salts, and disruption of BSEP function is often associated with altered hepatic homeostasis of bile acids and cholestatic liver injury. Accumulating evidence suggests that many drugs can cause cholestasis th...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3935137/ https://ncbi.nlm.nih.gov/pubmed/24335466 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.113.054189 |
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